背景:
Diffuse intrinsic pontine glioma (DIPG) is a universally fatal pediatric cancer.
A histone-3 K27M mutation affects ∼80% of DIPGs and drives aberrant transcription.
早在2015年的83个药物对14个DIPG细胞系的筛选实验中,就发现哪怕是效果最好的multi-HDAC inhibitor panobinostat也会被某些DIPG细胞系产生耐药性。(http://www.biotrainee.com/thread-1599-1-1.html) Continue reading