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居然还可以出售TCGA的数据,只有你稍微进行分析一下即可

亮瞎了我的双眼,原来还可以这样挣钱。
这个数据库的作者在2011年发了一篇如何寻找融合基因的文章:*Edgren, Henrik, et al. "Identification of fusion genes in breast cancer by paired-end RNA-sequencing." Genome Biol 12.1 (2011): R6.

然后基于此,把TCGA计划里面的所有癌症样本数据都处理了,并且得到了融合基因数据集,然后就以此出售

价格高达一万欧元,折合人民币七万多,一本万利,而且人家TCGA计划的数据的公开而且免费的,他做了二次处理就可以拿来挣钱,让我感觉很不爽。
到目前为止他们处理了TCGA计划里面的7652个癌症样本的数据,建立了一个囊括28种癌症的融合基因数据集,并且打包成了一个叫做FusionSCOUT 的产品来出售。
价格如下:

Pricing of FusionSCOUT datasets:

  • Single gene in one cancer set                        490€    /  580$ per dataset
  • Single gene fusions across all cancers          4900€  /  5800$ dataset
  • Individual cancer set                                       990 €   /  1250 $ per dataset
  • Full TCGA dataset                                          9900€  /  12500$ per dataset
该网站是这样介绍他们的产品的,号称有3500个研究团体已经使用了他们的数据,但是我感觉纯粹是吹牛,毕竟他这篇文献也就一百多的引用量,再说3500次购买,就这一个产品就能让他成为亿万富翁了,想想都觉得可怕。而且这网站这么烂,中国访问速度是渣渣,也就是相当于失去了中国的所有土豪客户了,怎么可能还有3500的销量,搞笑!

One of the latest therapeutics angles in the fight against cancer is fusion genes and their regulation. To aid in fusion gene research and reveal the multitude of gene fusion event in cancer samples MediSapiens has developed a proprietary FusionSCOUT pipeline for identifying fusion genes from RNA sequencing datasets.

Currently we have analysed 7625 tumour samples from the TCGA project building a fusion gene dataset covering 28 different cancers within the TCGA project which can be accessed through our FusionSCOUT product.

Using this pipeline, we have discovered 3930 samples with gene fusions with 9667 different fusion genes. We´ve discovered numerous novel gene fusions as well as new cancer types in which previously known fusions appear.

You can now purchase these gene fusions datasets with few mouse clicks and get the worlds most comprehensive gene fusions from cancer sets within days

FusionSCOUT cancer Reports

With FusionSCOUT you can access the full listings of all fusion genes in specific cancer datasets. Find new leads for possible cause of the cancer, examine the pathways that are affected by different fusions, stratify patients by shared fusion genes or search for potential target for drugs and companion diagnostics.

Once you purchase a FusionSCOUT dataset we will send you a detailed report with information on the fused genes, sample ID from the TCGA dataset, fusion frequencies across the dataset as well as fusion mRNA sequences and lists of protein domains present in the fusion transcripts.

By ordering the MediSapiens FusionSCOUT dataset, you´ll get:

  • A list of all gene fusions that involve your gene of interest, across all TCGA cancer types
  • TCGA sample ID: s of the for the samples with fusions
  • Exact exon junctions for the fusions, including alternatively spliced variants and data on whether reading frame is retained
  • Detailed list of protein domains retained in the fusion genes
  • cDNA sequence for the fusion mRNAs

Contact us to access the most up-to-date and comprehensive datasets of fusion gene events in different cancers!contact@medisapiens.com

Check out also our Fusion Gene Detection pipeline service for your samples!

Dataset missing? Email us and well add your favorite dataset to FusionSCOUT!

FusionSCOUT Cancer sets, March 2015

Cancer type Number of samples Number of fusion genes
Acute Myeloid Leukemia, LAML 153 69
Adrenocortical carcinoma, ACC 79 115
Bladder Urothelial Carcinoma, BLCA 273 473
Brain Lower Grade Glioma, LGG 467 309
Breast Invasive Carcinoma, BRCA 1029 3267
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma, CESC 195 190
Colon Adenocarcinoma, COAD 287 212
Glioblastoma multiforme, GBM 170 379
Head and Neck Squamous Cell Carcinoma, HNSC 412 386
Kidney Chromophobe, KICH 66 19
Kidney Renal Clear Cell Carcinoma, KIRC 523 217
Kidney Renal Papillary Cell Carcinoma, KIRP 226 145
Liver Hepatocellular Carcinoma, LIHC 198 317
Lung Adenocarcinoma, LUAD 456 991
Lung Squamous Cell Carcinoma, LUSC 482 1374
Lymphoid Neoplasm Diffuse Large B-cell Lymphoma, DLBC 28 18
Mesothelioma, MESO 36 26
Ovarian Serous Cystadenocarcinoma, OV 420 1166
Pancreatic Adenocarcinoma, PAAD 84 46
Pheochromocytoma and Paraganglioma, PCPG 184 83
Prostate Adenocarcinoma, PRAD 336 859
Rectum Adenocarcinoma, READ 85 74
Sarcoma, SARC 161 799
Skin Cutaneous Melanoma, SKCM 355 620
Stomach Adenocarcinoma, STAD 190 311
Thyroid Carcinoma, THCA 506 195
Uterine Carcinosarcoma, UCS 57 229
Uterine Corpus Endometrial Carcinoma, UCEC 167 422