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	<title>生信菜鸟团 &#187; hapmap</title>
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		<title>hapmap计划资源收集</title>
		<link>http://www.bio-info-trainee.com/1183.html</link>
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		<pubDate>Sun, 15 Nov 2015 01:39:38 +0000</pubDate>
		<dc:creator><![CDATA[ulwvfje]]></dc:creator>
				<category><![CDATA[杂谈-随笔]]></category>
		<category><![CDATA[hapmap]]></category>

		<guid isPermaLink="false">http://www.bio-info-trainee.com/?p=1183</guid>
		<description><![CDATA[官网是：http://hapmap.ncbi.nlm.nih.gov/index &#8230; <a href="http://www.bio-info-trainee.com/1183.html">Continue reading <span class="meta-nav">&#8594;</span></a>]]></description>
				<content:encoded><![CDATA[<p>官网是：<a href="http://hapmap.ncbi.nlm.nih.gov/index.html.en">http://hapmap.ncbi.nlm.nih.gov/index.html.en</a></p>
<div>里面有教程：<a href="http://hapmap.ncbi.nlm.nih.gov/tutorials.html.en" target="_blank">http://hapmap.ncbi.nlm.nih.gov/tutorials.html.en</a></div>
<div>所有的数据都放在ncbi上面：<a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/">ftp://ftp.ncbi.nlm.nih.gov/hapmap/</a></div>
<div>现在一般用这个计划的数据主要是拿自己得到的突变数据来跟这个hapmap计划的人种突变数据对比。</div>
<div>有芯片数据，也有WES和WGS数据，随着时间的推进，平台也在更新：</div>
<div>
<pre>Jul 07 2009 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/raw_data/affy100k/">affy100k</a>
Mar 05 2010 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/raw_data/affy500k/">affy500k</a>
Jun 02 2010 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/raw_data/hapmap3_affy6.0/">hapmap3_affy6.0</a></pre>
<pre>当然，数据也在更新</pre>
<pre>Jul 07 2009 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/gbrowse/2005-03_phaseI/">2005-03_phaseI</a>
Dec 03 2009 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/gbrowse/2005-11_phaseII/">2005-11_phaseII</a>
Jul 07 2009 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/gbrowse/2007-03/">2007-03</a>
Jul 07 2009 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/gbrowse/2008-03/">2008-03</a>
Jul 07 2009 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/gbrowse/2008-07_phaseIII/">2008-07_phaseIII</a>
Jul 07 2009 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/gbrowse/2008-10_phaseII/">2008-10_phaseII</a>
Jul 07 2009 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/gbrowse/2009-01_phaseIII/">2009-01_phaseIII</a>
Jul 07 2009 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/gbrowse/2009-02_phaseII+III/">2009-02_phaseII+III</a>
Aug 18 2010 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/gbrowse/2010-05_phaseIII/">2010-05_phaseIII</a>
Sep 19 2010 00:00    Directory <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/gbrowse/2010-08_phaseII+III/">2010-08_phaseII+III</a></pre>
<pre>数据都被整合好了：</pre>
<ul>
<li><b>Bulk data</b>
<ul>
<li><a href="http://hapmap.ncbi.nlm.nih.gov/downloads/genotypes/?N=D">Genotypes</a>: Individual genotype data submitted to the DCC to date. <b>Phase 3</b> data is available in <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/genotypes/2009-01_phaseIII/plink_format/">PLINK format</a> and <a href="ftp://ftp.ncbi.nlm.nih.gov/hapmap/genotypes/2009-01_phaseIII/hapmap_format/">HapMap format</a>.</li>
<li><b><a href="http://hapmap.ncbi.nlm.nih.gov/downloads/frequencies/?N=D">Frequencies</a></b>: Allele &amp; genotype frequencies compiled from genotyping data submitted to the DCC to date. These have also been submitted to <a href="http://www.ncbi.nlm.nih.gov/SNP/">dbSNP</a> and should be available in the next dbSNP build.</li>
<li><a href="http://hapmap.ncbi.nlm.nih.gov/downloads/ld_data/?N=D">LD Data</a>: Linkage disequilibrium properties D', LOD , R<sup>2</sup> compiled from the genotype data to date</li>
<li><a href="http://hapmap.ncbi.nlm.nih.gov/downloads/phasing/?N=D">Phasing Data</a>: Phasing data generated using the PHASE software, compiled from the genotype data to date.</li>
<li><b><a href="http://hapmap.ncbi.nlm.nih.gov/downloads/allocated_snps/?N=D">Allocated SNPs</a></b>: dbSNP reference SNP clusters that have been picked and prioritized for genotyping according to several criteria (see info on <a href="http://hapmap.ncbi.nlm.nih.gov/downloads/snp_categories.html">how SNPs were selected</a>). The file 00README contains per-chromosome SNP counts and further details.</li>
<li><b><a href="http://hapmap.ncbi.nlm.nih.gov/downloads/cnv_data/?N=D">CNV Genotypes</a></b>: CNV data from HapMap3 samples.</li>
<li><b><a href="http://hapmap.ncbi.nlm.nih.gov/downloads/recombination/">Recombination rates and Hotspots</a></b>: Recombination rates and hotspots compiled from the genotyping data.</li>
<li><b><a href="http://hapmap.ncbi.nlm.nih.gov/downloads/assays/?N=D">SNP assays</a></b>: Details about assays submitted to the DCC to date. PCR primers, extension probes etc., specific to each genotyping platform.</li>
<li><b><a href="http://hapmap.ncbi.nlm.nih.gov/downloads/perlegen_amplicons/?N=D">Perlegen amplicons</a></b>: Details for mapping Perlegen amplicons to HapMap assayLSID. For primer sequences, see <a href="http://genome.perlegen.com/pcr">Perlegen's</a> Long Range PCR Amplicon data.</li>
<li><b><a href="http://hapmap.ncbi.nlm.nih.gov/downloads/raw_data/?N=D">Raw data</a></b>: Raw signal intensity data from HapMap genotypes. Currently includes data from Affymetrix GeneChip 100k and 500k Mapping Arrays.</li>
<li><b><a href="http://hapmap.ncbi.nlm.nih.gov/downloads/inferred_genotypes/?N=D">Inferred genotypes</a></b>: Genotypes inferred using the method of Burdick et al. Nat Genet 38:1002-4.</li>
<li><b><a href="http://hapmap.ncbi.nlm.nih.gov/downloads/mtDNA_and_chrY_haplogroups/?N=D">Mitochondrial and chrY haplogroups</a></b>: Classification of phase I HapMap samples into mtDNA and chrY haplogroups. The distribution shown in Table 4 of the HapMap phase I paper <i>(Nat Genet 38:1002-4)</i> corresponds to unrelated parents in each one of the populations analyzed.</li>
</ul>
</li>
</ul>
<pre>同时也发了很多篇文章：</pre>
<ul>
<li>The International HapMap Consortium.<b> Integrating common and rare genetic variation in diverse human populations.</b><br />
<i>Nature</i> 467, 52-58. 2010. [<a href="http://www.nature.com/nature/journal/v467/n7311/abs/nature09298.html">Abstract</a>] [<a href="http://hapmap.ncbi.nlm.nih.gov/downloads/presentations/nature09298.pdf">PDF</a>] [<a href="http://hapmap.ncbi.nlm.nih.gov/downloads/presentations/nature09298-s1.pdf">Supplementary information</a>]</li>
<li>The International HapMap Consortium.<b> A second generation human haplotype map of over 3.1 million SNPs.</b><br />
<i>Nature</i> 449, 851-861. 2007. [<a href="http://www.nature.com/nature/journal/v449/n7164/abs/nature06258.html">Abstract</a>] [<a href="http://hapmap.ncbi.nlm.nih.gov/downloads/presentations/nature_hapmap3.pdf">PDF</a>] [<a href="http://hapmap.ncbi.nlm.nih.gov/downloads/presentations/nature_supp3.pdf">Supplementary information</a>]</li>
<li>The International HapMap Consortium. <b>A Haplotype Map of the Human Genome. </b><br />
<i>Nature</i> 437, 1299-1320. 2005. [<a href="http://www.nature.com/nature/journal/v437/n7063/abs/nature04226.html">Abstract</a>] [<a href="http://hapmap.ncbi.nlm.nih.gov/downloads/presentations/Nature_HapMap_phaseI.pdf">PDF</a>] [<a href="http://www.nature.com/nature/journal/v437/n7063/suppinfo/nature04226.html">Supplementary information</a>]</li>
<li>The International HapMap Consortium.<b> The International HapMap Project.</b><br />
<i>Nature</i> 426, 789-796. 2003. [<a href="http://www.nature.com/nature/journal/v426/n6968/abs/nature02168.html">Abstract</a>] [<a href="http://hapmap.ncbi.nlm.nih.gov/downloads/nature02168.pdf">PDF</a>] [<a href="http://www.nature.com/nature/journal/v426/n6968/suppinfo/nature02168.html">Supplementary information</a>]</li>
<li>The International HapMap Consortium. <b>Integrating Ethics and Science in the International HapMap Project. </b><br />
<i>Nature Reviews Genetics</i> 5, 467 -475. 2004. [<a href="http://www.nature.com/cgi-taf/DynaPage.taf?file=/nrg/journal/v5/n6/abs/nrg1351_fs.html&amp;dynoptions=doi1085422099">Abstract</a>] [<a href="http://hapmap.ncbi.nlm.nih.gov/downloads/HapMapEthics.pdf">PDF</a>]</li>
<li>Thorisson, G.A., Smith, A.V., Krishnan, L., and Stein, L.D. <b>The International HapMap Project Web site.</b><br />
<i>Genome Research</i>,15:1591-1593. 2005. [<a href="http://www.genome.org/cgi/content/abstract/15/11/1591">Abstract</a>] [<a href="http://hapmap.ncbi.nlm.nih.gov/downloads/presentations/Genome_research_art10.pdf">PDF</a>]</li>
</ul>
</div>
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