此工具的出现主要是为了解决基因组上面的非编码区域注释缺乏的问题，而我们CHIP-seq实验得到的peaks结果通常就是在非编码区域

首先进入该工具主页：http://bejerano.stanford.edu/great/public/html/

该工具每次只能上传一个文件，就是我们call出来的peaks记录文件，支持bed格式的：

一般很快就可以出结果啦！

首先会有三个图，都是很常见的，大家随便看看咯

Number of associated genes per region

Binned by orientation and distance to TSS

Binned by absolute distance to TSS

然后就是pathway和GO注释啦

这个网站提供的pathway非常之多，还是蛮全面的，包括KEGG，biocarta,reactome,msigdb等等还有一些signature和gene families，相当于一站式完成了大部分下游分析

 GO Molecular Function (no terms)

GO Biological Process (no terms)

 GO Cellular Component (no terms)

The test set of 5,225 genomic regions picked 2,992 (17%) of all 18,041 genes.
GO Molecular Function has 3,688 terms covering 15,090 (84%) of all 18,041 genes, and 189,388 term - gene associations.

The test set of 5,225 genomic regions picked 2,992 (17%) of all 18,041 genes.
GO Biological Process has 10,440 terms covering 15,441 (86%) of all 18,041 genes, and 950,065 term - gene associations.

The test set of 5,225 genomic regions picked 2,992 (17%) of all 18,041 genes.
GO Biological Process has 10,440 terms covering 15,441 (86%) of all 18,041 genes, and 950,065 term - gene associations.

Mouse Phenotype (no terms)

Human Phenotype (no terms)

 Disease Ontology (no terms)

MSigDB Cancer Neighborhood (no terms)

 Placenta Disorders (no terms)

PANTHER Pathway (no terms)

BioCyc Pathway (no terms)

MSigDB Pathway (no terms)

MGI Expression: Detected (no terms)

MSigDB Perturbation (no terms)

MSigDB Predicted Promoter Motifs (no terms)

MSigDB miRNA Motifs (no terms)

InterPro (no terms)

InterPro (no terms)

HGNC Gene Families (no terms)

 MSigDB Oncogenic Signatures (no terms)

MSigDB Immunologic Signatures (no terms)

The test set of 5,225 genomic regions picked 2,992 (17%) of all 18,041 genes.
MSigDB Immunologic Signatures has 1,910 terms covering 16,609 (92%) of all 18,041 genes, and 363,333 term - gene associations.